Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Endocrinology and Metabolism
;
: 331-334, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-141175
ABSTRACT
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Rabdomiólise
/
Hemofiltração
/
Músculo Esquelético
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Injúria Renal Aguda
/
Hipercolesterolemia
/
Hipotireoidismo
/
Músculos
/
Mioglobina
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS