Cancer Stem Cells / 한국유방암학회지
Journal of Breast Cancer
;
: 173-179, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-141314
ABSTRACT
Recent results have supported the cancer stem cells hypothesis in which tumors originate from tissue stem cells or their early progenitors and, as a result, produce tumors that retain stem cell properties. These properties include selfrenewal that drives tumorigenesis and differentiation that contributes to cellular heterogeneity. The number of these cells is very small, and is tightly controlled by the self-renewal pathway and the signals of their environment (niche). Evidence for the existence of cancer stem cells has been reported for a number of human cancers including leukemia, cancers of the breast, brain, and colon. Although our understanding of the biology of these cancer stem cells remains rudimentary, the existence of these cells has implications for current conceptualization of malignant transformation and targeted therapy for the treatment of cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco
/
Células-Tronco Neoplásicas
/
Características da População
/
Biologia
/
Encéfalo
/
Mama
/
Leucemia
/
Colo
/
Carcinogênese
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Breast Cancer
Ano de publicação:
2007
Tipo de documento:
Artigo
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