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Pain Palliation in Patients with Bone Metastases Using Magnetic Resonance-Guided Focused Ultrasound with Conformal Bone System: A Preliminary Report
Yonsei Medical Journal ; : 503-509, 2015.
Artigo em Inglês | WPRIM | ID: wpr-141612
ABSTRACT

PURPOSE:

We evaluated the safety and effectiveness of the Magnetic Resonance-guided Focused Ultrasound (MRgFUS) with the ExAblate Conformal Bone System for the palliation of painful bone metastases. MATERIALS AND

METHODS:

Our Institutional Review Board approved this study, and all patients gave informed consent prior to enrollment. A total of six painful metastatic bone lesions in five patients were treated using MRgFUS with the ExAblate Conformal Bone System for pain palliation. The follow-up sessions were at 3 days, 2 weeks, 1, 2, and 3 months, and 1 year after treatment. Efficacy was evaluated by the changes in visual analog scale (VAS) scores. At 3-months and 1-year follow-ups, unenhanced computed tomography and contrast-enhanced MR imaging examinations were performed. All adverse events were assessed to evaluate treatment safety.

RESULTS:

All patients showed significant pain relief within 2 weeks. Two patients experienced complete pain reduction that lasted for 1 year. Two other patients showed pain relief measured as VAS scores of 2 and 4 on their last follow-up. Although the remaining patient had experienced significant pain relief in two lesions, the VAS score re-increased on his last follow-up. The size of the enhancing soft tissue mass in metastatic lesions decreased, and new bone formation was seen on follow-up images. Although adverse events were not serious, non-specific leg pain and second degree skin burn were noted.

CONCLUSION:

MRgFUS was demonstrated to be effective palliative treatment within 2 weeks in selected patients with painful bone metastases.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor / Cuidados Paliativos / Neoplasias Ósseas / Espectroscopia de Ressonância Magnética / Tomografia Computadorizada por Raios X / Estudos Prospectivos / Resultado do Tratamento / Meios de Contraste / Imagem por Ressonância Magnética Intervencionista / Ablação por Ultrassom Focalizado de Alta Intensidade Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor / Cuidados Paliativos / Neoplasias Ósseas / Espectroscopia de Ressonância Magnética / Tomografia Computadorizada por Raios X / Estudos Prospectivos / Resultado do Tratamento / Meios de Contraste / Imagem por Ressonância Magnética Intervencionista / Ablação por Ultrassom Focalizado de Alta Intensidade Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2015 Tipo de documento: Artigo