Effects of Topical Tamoxifen on Wound Healing of Burned Skin in Rats
Archives of Plastic Surgery
;
: 378-383, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-142238
ABSTRACT
BACKGROUND:
This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue.METHODS:
Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals’ back, measuring 2×2×2 cm. In the first group, a 2% tamoxifen ointment was applied to the wound twice daily for 8 weeks. The second group received a placebo ointment during the same period. The third group did not receive any treatment and served as the control group.RESULTS:
The median (interquartile range=[Q1, Q3]) FTT was 1.35 (1.15, 1.62) mm, 1.00 (0.95, 1.02) mm, and 1.25 (0.8, 1.5) mm in the control, tamoxifen, and placebo groups, respectively (P=0.069). However, the FTT in the tamoxifen group was less than in the placebo and control groups. The median angiogenesis was 3.5 (3.00, 6.25), 8.00 (6.75, 9.25), and 7.00 (5.50, 8.25) vessels per high-power field for the control, tamoxifen, and placebo groups, respectively (P=0.067). However, the median angiogenesis was higher in the tamoxifen group than in the control group. No significant difference was observed in the mean SSA between the tamoxifen group and the control group (P=0.990).CONCLUSIONS:
Local application of tamoxifen increased angiogenesis and decreased the FTT, with no change in the SSA in burned skin areas. These effects are expected to expedite the wound healing process, reducing contracture and preventing hypertrophic scar and keloid formation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Tamoxifeno
/
Cicatrização
/
Ferimentos e Lesões
/
Queimaduras
/
Cicatriz
/
Ratos Wistar
/
Cicatriz Hipertrófica
/
Contratura
/
Queloide
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Archives of Plastic Surgery
Ano de publicação:
2017
Tipo de documento:
Artigo
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