Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer's disease
Nutrition Research and Practice
; : 386-390, 2014.
Article
em En
| WPRIM
| ID: wpr-142636
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS: We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of beta-amyloid peptide (Abeta) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice. RESULTS: Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of Abeta1-42 until evaluation) effectively blocked Abeta1-42-induced impairment in passive avoidance performance, and Abeta1-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-1alpha in the hippocampus. In addition, it alleviated the Abeta1-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1beta in the brain. CONCLUSIONS: The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.
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Assunto principal:
Encéfalo
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Acetilcolina
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Administração Oral
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Interleucinas
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Placa Amiloide
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Eleutherococcus
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Doença de Alzheimer
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Proteína Glial Fibrilar Ácida
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Hipocampo
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Amiloide
Limite:
Animals
Idioma:
En
Revista:
Nutrition Research and Practice
Ano de publicação:
2014
Tipo de documento:
Article