Immunohistochemical Study of the Expression of Astrocyte Elevated Gene-1 (AEG-1) in Malignant Melanoma, Spitz Nevus and Dysplastic Nevus / 대한피부과학회지
Korean Journal of Dermatology
; : 334-338, 2011.
Article
em Ko
| WPRIM
| ID: wpr-142661
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: The astrocyte elevated gene-1 (AEG-1) was cloned as a novel HIV-1 and tumor necrosis factor-alpha-induced transcript from primary human fetal astrocytes. It has been reported that the AEG-1 expression is elevated in subsets of breast cancer, glioblastoma multiforme and melanoma cells, and AEG-1 cooperates with Ha-ras to promote the transformation of immortalized melanocytes. AEG-1 is thought to play a role in promoting cancer development and/or its maintenance. OBJECTIVE: The aim of this study is to determine whether AEG-1 is related to the pathogenesis of melanoma and other melanocytic lesions. METHODS: The nine biopsy specimens each of melanoma, dysplastic nevus, Spitz nevus and compound nevus were studied using immunohistochemical staining. The expressions of AEG-1 were evaluated using an immunostaining-intensity-distribution index. RESULTS: The expression of AEG-1 was significantly higher in the melanoma and dysplastic nevus than in the compound nevus. The expression was also significantly higher in the melanoma than in the Spitz nevus. CONCLUSION: AEG-1 may be related to the pathogenesis of both dysplastic nevus and melanoma, but it may not be related to Spitz nevus.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Biópsia
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Síndrome do Nevo Displásico
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Neoplasias da Mama
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Astrócitos
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HIV-1
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Células Clonais
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Nevo de Células Epitelioides e Fusiformes
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Glioblastoma
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Melanócitos
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Melanoma
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Dermatology
Ano de publicação:
2011
Tipo de documento:
Article