Immunohistochemical Study of the Expression of Astrocyte Elevated Gene-1 (AEG-1) in Malignant Melanoma, Spitz Nevus and Dysplastic Nevus / 대한피부과학회지
Korean Journal of Dermatology
;
: 334-338, 2011.
Artigo
em Coreano
| WPRIM
| ID: wpr-142661
ABSTRACT
BACKGROUND:
The astrocyte elevated gene-1 (AEG-1) was cloned as a novel HIV-1 and tumor necrosis factor-alpha-induced transcript from primary human fetal astrocytes. It has been reported that the AEG-1 expression is elevated in subsets of breast cancer, glioblastoma multiforme and melanoma cells, and AEG-1 cooperates with Ha-ras to promote the transformation of immortalized melanocytes. AEG-1 is thought to play a role in promoting cancer development and/or its maintenance.OBJECTIVE:
The aim of this study is to determine whether AEG-1 is related to the pathogenesis of melanoma and other melanocytic lesions.METHODS:
The nine biopsy specimens each of melanoma, dysplastic nevus, Spitz nevus and compound nevus were studied using immunohistochemical staining. The expressions of AEG-1 were evaluated using an immunostaining-intensity-distribution index.RESULTS:
The expression of AEG-1 was significantly higher in the melanoma and dysplastic nevus than in the compound nevus. The expression was also significantly higher in the melanoma than in the Spitz nevus.CONCLUSION:
AEG-1 may be related to the pathogenesis of both dysplastic nevus and melanoma, but it may not be related to Spitz nevus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biópsia
/
Síndrome do Nevo Displásico
/
Neoplasias da Mama
/
Astrócitos
/
HIV-1
/
Células Clonais
/
Nevo de Células Epitelioides e Fusiformes
/
Glioblastoma
/
Melanócitos
/
Melanoma
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2011
Tipo de documento:
Artigo
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