The Efficiency of Plasma Exchange for Renal Allograft Recipients with HLA Antibody before Transplantation / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 1-8, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-14271
ABSTRACT
BACKGROUND:
Therapeutic plasma exchange (TPE) is used to remove antibodies from the blood stream, thereby preventing them from attacking their targets. We evaluated the strategies to increase the efficiency of TPE for renal allograft recipients with HLA antibody.METHODS:
A total of 11 patients were evaluated from January 2002 to April 2004. All the patients had been diagnosed with end stage renal disease (ESRD) and then they were scheduled for renal transplantation from a living unrelated donor or a living related donor. TPE was performed for all lymphocyte cross-matching (LCM) positive recipients before renal transplantation. One to three sessions of TPE were performed in 8 patients and four to seven sessions of TPE were performed in 3 patients (mean 2.81 times). We used normal saline and 4% albumin as a replacement solution.RESULTS:
Eleven patients, after the patients' LCM positive serum converted to negative, received the renal transplantation. Of the 11 recipients, only 1 recipient suffered from chronic rejection. Ten recipients maintained normal renal function. Among the 11 recipients, 4 recipients were diagnosed with posttransplantation diabetes mellitus. 3 recipients had a past history of graft failure via acute or chronic rejection. Even these 3 recipients experienced successful renal allograft through pre-transplantation TPE. Also, all the recipients were followed up until June, 2005.CONCLUSION:
For ESRD patients with positive LCM, pre-transplantation TPE dramatically decreases the incidence of acute or chronic rejections by converting positive LCM into negative LCM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Troca Plasmática
/
Doadores de Tecidos
/
Linfócitos
/
Incidência
/
Transplante de Rim
/
Transplantes
/
Rios
/
Diabetes Mellitus
/
Doadores não Relacionados
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Blood Transfusion
Ano de publicação:
2007
Tipo de documento:
Artigo
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