Orbito-Frontal Cortex Volumes in Panic Disorder
Psychiatry Investigation
;
: 408-412, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-14288
ABSTRACT
OBJECTIVE:
Given the association between the pathophysiology of panic disorder and prefrontal cortex function, we aimed to perform a volumetric MRI study in patients with panic disorder and healthy controls focusing on the in vivo neuroanatomy of the OFC.METHODS:
Twenty right-handed patients with panic disorder and 20 right-handed healthy control subjects were studied. The volumes of whole brain, total white and gray matters, and OFC were measured by using T1-weighted coronal MRI images, with 1.5-mm-thick slices, at 1.5T. In addition, for psychological valuation, Hamilton Depression Rating (HDRS) and Panic Agoraphobia Scales (PAS) were administered.RESULTS:
Unadjusted mean volumes of the whole brain volume, total white and gray matter were not different between the patients and healthy controls while the patient group had significantly smaller left (t=-6.70, p<0.0001) and right (t=-5.86, p<0.0001) OFC volumes compared with healthy controls.CONCLUSION:
Our findings indicate an alteration of OFC morphology in the panic disorder and suggest that OFC abnormalities may be involved in the pathophysiology of panic disorder.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pânico
/
Pesos e Medidas
/
Encéfalo
/
Transtorno de Pânico
/
Córtex Pré-Frontal
/
Agorafobia
/
Depressão
/
Neuroanatomia
Limite:
Humanos
Idioma:
Inglês
Revista:
Psychiatry Investigation
Ano de publicação:
2012
Tipo de documento:
Artigo
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