Hemodynamic changes associated with a novel concentration of lidocaine HCl for impacted lower third molar surgery
Journal of Dental Anesthesia and Pain Medicine
;
: 121-128, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-143039
ABSTRACT
BACKGROUND:
The authors studied the hemodynamic effect influent by using the novel high concentration of lidocaine HCl for surgical removal impacted lower third molar. The objective of this study was to evaluate the hemodynamic change when using different concentrations of lidocaine in impacted lower third molar surgery.METHODS:
Split mouth single blind study comprising 31 healthy patients with a mean age of 23 years (range 19-33 years). Subjects had symmetrically impacted lower third molars as observed on panoramic radiograph. Each participant required 2 surgical interventions by the same surgeon with a 3-week washout period washout period. The participants were alternately assigned one of two types of local anesthetic (left or right) for the first surgery, then the other type of anesthetic for the second surgery. One solution was 4% lidocaine with 1100,000 epinephrine and the other was 2% lidocaine with 1100,000 epinephrine. A standard IANB with 1.8 ml volume was used. Any requirement for additional anesthetic and patient pain intra-operation was recorded. Post-operatively, patient was instructed to fill in the patient report form for any adverse effect and local anesthetic preference in terms of intra-operative pain. This form was collected at the seven day follow up appointment.RESULTS:
In the 4% lidocaine group, the heart rate increased during the first minute post-injection (P < 0.05). However, there was no significant change in arterial blood pressure during the operation. In the 2% lidocaine group, there was a significant increase in arterial blood pressure and heart rate in the first minute following injection for every procedure. When the hemodynamic changes in each group were compared, the 4% lidocaine group had significantly lower arterial blood pressure compared to the 2% lidocaine group following injection. Post-operatively, no adverse effects were observed by the operator and patient in either local anesthetic group. Patients reported less pain intra-operation in the 4% lidocaine group compared with the 2% lidocaine group (P < .05).CONCLUSIONS:
Our results suggest that a 4% concentration of lidocaine HCl with 1100,000 epinephrine has better clinical efficacy than 2% lidocaine HCl with 1100,000 epinephrine when used for surgical extraction of lower third molars. Neither drug had any clinical adverse effects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Epinefrina
/
Método Simples-Cego
/
Seguimentos
/
Resultado do Tratamento
/
Pressão Arterial
/
Frequência Cardíaca
/
Hemodinâmica
/
Lidocaína
/
Dente Serotino
/
Boca
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Dental Anesthesia and Pain Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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