Your browser doesn't support javascript.
loading
The outcome of short-term low-dose aspirin treatment in Kawasaki disease based on inflammatory markers / 소아과
Korean Journal of Pediatrics ; : 24-29, 2017.
Artigo em Inglês | WPRIM | ID: wpr-143206
ABSTRACT

PURPOSE:

Previously, Kawasaki disease (KD) treatment with low-dose aspirin was administered for 6–8 weeks after the acute phase. However, inflammatory marker levels normalize before 6–8 weeks. In this study, we aimed to investigate the clinical outcome of short-term low-dose aspirin treatment based on inflammatory and thrombotic marker levels.

METHODS:

We performed a retrospective review of the medical records of patients with KD who were hospitalized at Chungnam National University Hospital between September 2012 and May 2014. When fever subsided, low-dose aspirin treatment was started. Inflammatory (white blood cell count, erythrocyte sedimentation rate, and C-reactive protein) and thrombotic markers (D-dimer) were monitored at follow-ups conducted in 1- to 2-week intervals. The low-dose aspirin administration was terminated when both markers were normalized and no cardiovascular complications were observed.

RESULTS:

Eighty-four patients with KD (complete KD, n=49; incomplete KD, n=35) were enrolled. The inflammatory and thrombotic marker levels were normalized within 3–4 weeks on average. At the beginning the low-dose aspirin treatment, 9 patients had coronary artery lesions but 75 did not. When the low-dose aspirin administration was terminated at the time the inflammatory marker levels were normalized, no new CALs developed during the follow-up at 6–8 weeks.

CONCLUSION:

Most of the inflammatory marker levels were normalized within 3–4 weeks after the acute phase of KD. New cardiovascular complications did not develop during the course of the short-term aspirin treatment based on the inflammatory marker levels, clinical findings, and echocardiography.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Contagem de Células Sanguíneas / Sedimentação Sanguínea / Ecocardiografia / Aspirina / Prontuários Médicos / Estudos Retrospectivos / Seguimentos / Vasos Coronários / Febre / Inflamação Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Korean Journal of Pediatrics Ano de publicação: 2017 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Contagem de Células Sanguíneas / Sedimentação Sanguínea / Ecocardiografia / Aspirina / Prontuários Médicos / Estudos Retrospectivos / Seguimentos / Vasos Coronários / Febre / Inflamação Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Korean Journal of Pediatrics Ano de publicação: 2017 Tipo de documento: Artigo