Association of Early Postnatal Neutropenia and Development of Bronchopulmonary Dysplasia in Preterm Infants
Journal of the Korean Pediatric Society
; : 1033-1060, 1998.
Article
em Ko
| WPRIM
| ID: wpr-143510
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To see if a similar relationship exists between the decreased number of circulating neutrophils and the development of bronchopulmonary dysplasia (BPD) in preterm infants, we tried to test the hypothesis that claims that preterm infants, who develop BPD, have decreased number of circulating neutrophils than those who do not develop BPD. METHODS: A retrospective cohort study was conducted in 167 preterm infants from August 1995 to July 1997, who were admitted in the neonatal intensive care unit (NICU) of Seoul National University Children's Hospital. RESULTS: BPD was diagnosed in 16% (27/167) of preterm infants. We compared the clinical characteristics of the study population according to the presence or absence of BPD. Compared to non-BPD group, the BPD group had a lower gestational age (29.4 +/- 2.7weeks versus 32.7 +/- 1.7 weeks), lower birth weight (1,240 +/- 486g versus 1,780 +/- 420g), lower incidence of prenatal steroid use (2/27 versus 41/140), decreased number of circulating neutrophils (3,622 +/- 4,866/microliter versus 7,586 +/- 4,545/microliter) at 1 day of life. After adjusting for the variables of the above risk factors, neutropenia (<2,500/microliter) in the peripheral blood increased the odds ratio of developing BPD (OR : 46.3, 95% CI : 17.3-117.2). CONCLUSION: Early postnatal neutropenia might be an important risk factor for the development of BPD and lung injury responsible for the development of BPD might begin at the early postnatal period.
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WPRIM
Assunto principal:
Peso ao Nascer
/
Displasia Broncopulmonar
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Recém-Nascido Prematuro
/
Terapia Intensiva Neonatal
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Razão de Chances
/
Incidência
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Estudos Retrospectivos
/
Fatores de Risco
/
Estudos de Coortes
/
Idade Gestacional
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Newborn
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Journal of the Korean Pediatric Society
Ano de publicação:
1998
Tipo de documento:
Article