Pathophysiological Implications of Sodium Transporters and Water Channels in the Kidney / 대한신장학회지
Korean Journal of Nephrology
;
: 1-9, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-143758
ABSTRACT
Renal sodium and water reabsorption occurs through epithelial sodium transporters and aquaporin (AQP) water channels in various segments of tubules. We have demonstrated altered regulation of these transporters and channels in various pathophysiological conditions. In nephrotic syndrome and liver cirrhosis, expression of epithelial sodium channels (ENaC) was increased in the late distal convoluted tubule, connecting tubule, and collecting duct. In spontaneously hypertensive rats, the expression of Na,K-ATPase as well as that of ENaC was increased. In contrast, AQP1-3 and sodium transporters was decreased in the kidney from deoxycorticosterone acetate-salt hypertension. In two-kidney, one clip hypertension, the expression of Na,K-ATPase, NHE3, NKCC2 and ENaC subunits was decreased in the clipped kidney while remained unchanged in the contralateral kidney. We have also shown an increased activity of renal atrial natriuretic peptide system in postobstructive natriuresis/ diuresis. In acute kidney injury (cisplatin-, gentamicin- and ischemia/reperfusion-induced), the expression of Na,K-ATPase, NHE3, NKCC2 and AQP1-3 was decreased. The altered regulation of sodium transporters and AQP may be causally related with various kidney diseases and hypertension.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ratos Endogâmicos SHR
/
Sódio
/
Aquaporinas
/
Desoxicorticosterona
/
Diurese
/
Canais Epiteliais de Sódio
/
Injúria Renal Aguda
/
Hipertensão
/
Rim
/
Nefropatias
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2009
Tipo de documento:
Artigo
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