Study of Prostate Volume, Age, Serum Prostate Specific Antigen and Testosterone in Patients with Benign Prostate Hyperplasia with Lower Urinary Tract Symptoms / 대한남성과학회지

ABSTRACT

PURPOSE: The development of benign prostate hyperplasia(BPH) is attributed to aging and the presence of testis. We studied the relationships between serum prostate specific antigen(PSA), testosterone, age, andprostate volume in patients with BPH with lower urinary tract symptoms(LUTS). MATERIALS AND METHODS: From January 2003 to June 2004, 197 men with BPH with LUTS were evaluated for prostate volume with transrectal ultrasonography. From a serum sample collected between 9 and 11 AM, total PSA, free PSA, serum total testosterone, and free testosterone were measured. RESULTS: The average age was 61.0+/-11.3 years, and the average prostate volume was 34.2+/-16.7 ml. Age had a significant correlation with total PSA, free PSA, and prostate volume but an inverse correlation with free testosterone. Also, prostate volume showed a significant correlation with serum total PSA and free PSA but an inverse correlation with free testosterone. CONCLUSIONS: Age correlates positively with serum PSA and prostate volume but negatively with serum free testosterone. Prostate volume correlates positively with serum PSA but negatively with serum free testosterone.