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Treatment outcome and risk analysis for cataract after radiotherapy of localized ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma
Radiation Oncology Journal ; : 249-256, 2017.
Artigo em Inglês | WPRIM | ID: wpr-144706
ABSTRACT

PURPOSE:

We retrospectively reviewed the results of radiotherapy for localized ocular adnexal MALT lymphoma (OAML) to investigate the risk factors of cataract.

METHODS:

Sixty-seven patients with stage IE OAML treated with radiotherapy at Seoul St. Mary's Hospital from 2001 to 2016 were included. Median treatment dose was 30 Gy. Lens protection was done in 52 (76%) patients. Radiation therapy (RT) extent was as follows superficial (82.1%), tumor mass (4.5%), and entire orbital socket (13.4%). The risk factors for symptomatic cataract were analyzed using the Cox proportional hazard model.

RESULTS:

Median follow-up time was 50.9 months (range, 1.9 to 149.4 months). All patients were alive at the time of analysis. There were 7 recurrences and there was no local recurrence. Median time to recurrence was 40.4 months. There were 14 cases of symptomatic cataract. Dose >30 Gy had hazard ratio of 3.47 for cataract (p = 0.026). Omitting lens protection showed hazard ratio of 4.10 (p = 0.008).

CONCLUSIONS:

RT achieves excellent local control of ocular MALT lymphoma. Consideration of RT-related factors such as lens protection and radiation dose at the stage of RT planning may reduce the risk of RT-induced cataract after radiotherapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Órbita / Radioterapia / Recidiva / Catarata / Modelos de Riscos Proporcionais / Estudos Retrospectivos / Fatores de Risco / Seguimentos / Resultado do Tratamento / Linfoma de Zona Marginal Tipo Células B Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Radiation Oncology Journal Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Órbita / Radioterapia / Recidiva / Catarata / Modelos de Riscos Proporcionais / Estudos Retrospectivos / Fatores de Risco / Seguimentos / Resultado do Tratamento / Linfoma de Zona Marginal Tipo Células B Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Radiation Oncology Journal Ano de publicação: 2017 Tipo de documento: Artigo