Pro-apoptotic function of hepatitis B virus X protein / 대한간학회지
The Korean Journal of Hepatology
;
: 112-122, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-14489
ABSTRACT
Infection of hepatitis B virus (HBV) is a main cause of liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Among the HBV-encoded proteins, the HBV X protein (HBx) has been suspected to be strongly involved in HBV-associated liver pathogenesis. HBx, a virally encoded multifunctional regulator, has been shown to induce apoptosis, anti-apoptosis, proliferation, and transformation of cells depending on the cell lines, model systems used, assay protocols, and research groups. Among the several activities of HBx, the pro-apoptotic function of HBx will be discussed in this review. Given that the disruption of apoptosis pathway by HBx contributes to the liver pathogenesis, a better understanding of the molecular interference in the cellular pro-apoptotic networks by HBx will provide useful clues for the intervention in HBV-mediated liver diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transativadores
/
Proteína Supressora de Tumor p53
/
Apoptose
/
Fatores de Necrose Tumoral
/
Hepatite B
/
Hepatopatias
Tipo de estudo:
Estudo prognóstico
Idioma:
Coreano
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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