Filtration Effects of Leukocyte Removal Filter for Platelet Concentrates / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 241-245, 1996.
Article
em Ko
| WPRIM
| ID: wpr-145323
Biblioteca responsável:
WPRO
ABSTRACT
Some variables can influence the efficiency of leukocyte removal filter for red cell concentrates. We performed this study to evaluate whether the filtration efficiency for platelet concentrates(PCs) can be influenced by bedside filter(PXL8K, Pall Corporation, USA) used, platelet storage time and transient stopping of platelet agitation, and to measure the amount of cytokines released from donor leukocytes in PCs during the storage time. In addition, we examined the effect of leukocyte reduction by filtration before the storage of PCs on the subsequent generation of cytokines. Any of the above mentioned variables did not make significant differences. From day 1 to day 5, there were significant increases in IL-1 beta (<1 vs. 8.6 pg/mL, p<0.05), IL-8 (<10 vs. 455.3 pg/mL, p<0.05) and TNF-alpha (<4 vs. 16.6 pg/mL, p<0.05) in unflltered PCs, whereas no increased revels of cytokines were found in the cases of prestorage filtration.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Doadores de Tecidos
/
Plaquetas
/
Citocinas
/
Interleucina-8
/
Fator de Necrose Tumoral alfa
/
Di-Hidroergotamina
/
Interleucina-1beta
/
Filtração
/
Leucócitos
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Blood Transfusion
Ano de publicação:
1996
Tipo de documento:
Article