A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma
Immune Network
;
: 126-128, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-145818
ABSTRACT
We report on a case of severe hepatotoxicity in a 52-year-old male with multiple myeloma (MM) who had received bortezomib therapy. At patient presentation, liver enzymes were normal, but started to markedly increase 3 days after the patient's second dose of bortezomib was administered, when free kappa light chains were noticeably reduced in the serum. After discontinuation of bortezomib, liver enzymes recovered gradually to baseline. Then, the patient was started on a thalidomide-containing regimen, which he was able to tolerate well. The patient achieved complete remission prior to autologous stem cell transplantation (ASCT). The patient underwent ASCT without occurrence of further liver toxicity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pirazinas
/
Ácidos Borônicos
/
Transplante de Células-Tronco
/
Doença Hepática Induzida por Substâncias e Drogas
/
Bortezomib
/
Luz
/
Fígado
/
Mieloma Múltiplo
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2012
Tipo de documento:
Artigo
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