Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells
Experimental & Molecular Medicine
; : 551-556, 2004.
Article
em En
| WPRIM
| ID: wpr-145925
Biblioteca responsável:
WPRO
ABSTRACT
Pseudolaric acid B was isolated from Pseudolarix kaempferi Gordon (Pinaceae) and was evaluated for the anti-cancer effect in HeLa cells. We observed that pseudolaric acid B inhibited cell proliferation and induced apoptosis in a time- and dose-dependent manner. HeLa cells treated with pseudolaric acid B showed typical characteristics of apoptosis including the morphological changes and DNA fragmentation. JNK inhibitor, SP600125, markedly inhibited pseudolaric acid B-induced cell death. In addition, Bcl-2 expression was down-regulated while Bax protein level was up-regulated. Caspase-3 inhibitor, z-DEVD-fmk, partially blocked pseudolaric acid B-induced cell death, and the expression of two classical caspase substrates, PARP and ICAD, were both decreased in a time- dependent manner, indicative of downstream caspase activation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oligopeptídeos
/
Células HeLa
/
Transdução de Sinais
/
Inibidores de Cisteína Proteinase
/
Regulação para Baixo
/
Regulação para Cima
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Caspases
/
Proteínas Quinases JNK Ativadas por Mitógeno
Limite:
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2004
Tipo de documento:
Article