Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm
Natural Product Sciences
; : 225-230, 2016.
Article
em En
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| ID: wpr-146024
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WPRO
ABSTRACT
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 – 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 – 504.2 µM and 21.0 – 59.4 µM, respectively.
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Índice:
WPRIM
Assunto principal:
Acetilcolina
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Lignanas
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Concentração Inibidora 50
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Ciclo-Oxigenase 2
Idioma:
En
Revista:
Natural Product Sciences
Ano de publicação:
2016
Tipo de documento:
Article