Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy
Kidney Research and Clinical Practice
;
: 139-143, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-146554
ABSTRACT
BACKGROUND:
Urinary kidney injury molecule-1 (KIM-1) is an early and sensitive biomarker of acute kidney injury, but it is unclear if it is a biomarker of chronic glomerulonephritis. We evaluated whether urinary KIM-1 levels in patients with immunoglobulin A (IgA) nephropathy can be a marker to reflect clinicopathological severity and predict the prognosis.METHODS:
We measured urinary KIM-1 levels in 40 patients (15 males; mean age 36.67+/-12.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age 37.37+/-9.6 years) as controls. The correlation of urinary KIM-1 levels with patients' clinical parameters, histological grades, and follow-up data were analyzed using the modified H. S. Lee grading system and tubulointerstitial change scores.RESULTS:
Urinary KIM-1 levels were higher in patients with IgA nephropathy than healthy controls (P=0.001). Univariate and multivariate regression analyses showed that urinary KIM-1 levels had a direct correlation with H. S. Lee grade and tubulointerstitial inflammation (P=0.004 and P=0.011, respectively).CONCLUSION:
In patients with IgA nephropathy, urinary KIM-1 has a significant correlation with histopathologic severity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Imunoglobulina A
/
Seguimentos
/
Injúria Renal Aguda
/
Glomerulonefrite
/
Glomerulonefrite por IGA
/
Inflamação
/
Rim
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2014
Tipo de documento:
Artigo
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