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Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy
Kidney Research and Clinical Practice ; : 139-143, 2014.
Artigo em Inglês | WPRIM | ID: wpr-146554
ABSTRACT

BACKGROUND:

Urinary kidney injury molecule-1 (KIM-1) is an early and sensitive biomarker of acute kidney injury, but it is unclear if it is a biomarker of chronic glomerulonephritis. We evaluated whether urinary KIM-1 levels in patients with immunoglobulin A (IgA) nephropathy can be a marker to reflect clinicopathological severity and predict the prognosis.

METHODS:

We measured urinary KIM-1 levels in 40 patients (15 males; mean age 36.67+/-12.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age 37.37+/-9.6 years) as controls. The correlation of urinary KIM-1 levels with patients' clinical parameters, histological grades, and follow-up data were analyzed using the modified H. S. Lee grading system and tubulointerstitial change scores.

RESULTS:

Urinary KIM-1 levels were higher in patients with IgA nephropathy than healthy controls (P=0.001). Univariate and multivariate regression analyses showed that urinary KIM-1 levels had a direct correlation with H. S. Lee grade and tubulointerstitial inflammation (P=0.004 and P=0.011, respectively).

CONCLUSION:

In patients with IgA nephropathy, urinary KIM-1 has a significant correlation with histopathologic severity.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Imunoglobulina A / Seguimentos / Injúria Renal Aguda / Glomerulonefrite / Glomerulonefrite por IGA / Inflamação / Rim Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Imunoglobulina A / Seguimentos / Injúria Renal Aguda / Glomerulonefrite / Glomerulonefrite por IGA / Inflamação / Rim Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2014 Tipo de documento: Artigo