MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
Experimental & Molecular Medicine
;
: e156-2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-147138
ABSTRACT
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6 production by macrophages in response to LPS has remained unclear, however. We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of reactive oxygen species (ROS) by NADPH oxidase 1 (Nox1) and consequent activation of the transcription factor nuclear factor (NF)-kappaB function downstream of BLT2 in this response. These results suggest that a TLR4-MyD88-BLT2-Nox1-ROS-NF-kappaB pathway contributes to the synthesis of IL-6 in LPS-stimulated mouse macrophages.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
Linhagem Celular
/
Lipopolissacarídeos
/
NF-kappa B
/
Interleucina-6
/
Espécies Reativas de Oxigênio
/
Receptores do Leucotrieno B4
/
Macrófagos Peritoneais
/
Leucotrieno B4
/
Fator 88 de Diferenciação Mieloide
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS