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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction
Yonsei Medical Journal ; : 291-297, 2016.
Artigo em Inglês | WPRIM | ID: wpr-147363
ABSTRACT
Mild therapeutic hypothermia of 32-35degrees C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completely solved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewed rationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical application to the patients with acute myocardial infarction, lessons from current clinical trials and future directions.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fatores de Tempo / Temperatura Corporal / Traumatismo por Reperfusão Miocárdica / Doença Aguda / Resultado do Tratamento / Hipotermia Induzida / Infarto do Miocárdio Tipo de estudo: Ensaio Clínico Controlado / Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fatores de Tempo / Temperatura Corporal / Traumatismo por Reperfusão Miocárdica / Doença Aguda / Resultado do Tratamento / Hipotermia Induzida / Infarto do Miocárdio Tipo de estudo: Ensaio Clínico Controlado / Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2016 Tipo de documento: Artigo