The Efficacy and Safety of Platelet-Rich Plasma and Adipose-Derived Stem Cells: An Update
Archives of Plastic Surgery
;
: 585-592, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-147456
ABSTRACT
During the past decade, many studies using platelet-rich plasma (PRP) or adipose-derived stem cells (ASCs) have been conducted in various medical fields, from cardiovascular research to applications for corneal diseases. Nonetheless, there are several limitations of practical applications of PRP and ASCs. Most reports of PRP are anecdotal and few include controls to determine the specific role of PRP. There is little consensus regarding PRP production and characterization. Some have reported the development of an antibody to bovine thrombin, which was the initiator of platelet activation. In the case of ASCs, good manufacturing practices are needed for the production of clinical-grade human stem cells, and in vitro expansion of ASCs requires approval of the Korea Food and Drug Administration, such that considerable expense and time are required. Additionally, some have reported that ASCs could have a potential risk of transformation to malignant cells. Therefore, the authors tried to investigate the latest research on the efficacy and safety of PRP and ASCs and report on the current state and regulation of these stem cell-based therapies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco
/
United States Food and Drug Administration
/
Trombina
/
Ativação Plaquetária
/
Resultado do Tratamento
/
Doenças da Córnea
/
Consenso
/
Plasma Rico em Plaquetas
/
Células-Tronco Mesenquimais
/
Coreia (Geográfico)
Tipo de estudo:
Guia de Prática Clínica
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Archives of Plastic Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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