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Changes in liver stiffness during the course of acute hepatitis A / 대한간학회지
The Korean Journal of Hepatology ; : 465-473, 2008.
Artigo em Inglês | WPRIM | ID: wpr-147561
ABSTRACT
BACKGROUNDS/

AIMS:

In some patients with chronic hepatitis, liver stiffness (LS) findings do not reflect fibrosis stage. This study was performed to evaluate whether acute liver inflammation could influence LS findings.

METHODS:

Patients with acute hepatitis A admitted to our hospital were included. Hepatitis was classified on admission using serum ALT and bilirubin levels as inflammation phase, jaundice phase, or recovery phase. Patients who admitted during the recovery phase (whose ALT and bilirubin levels fell continuously during hospitalization) and therefore, their peak-ALT and peak bilirubin levels could not be determined were exduded. Enrolled patients underwent FibroScan during hospitalization and after discharge.

RESULTS:

Seventy-six patients with acute hepatitis A were enrolled (median age, 29 years; 46 men and 30 women). Among them, 33 (43.4%) and 43 (56.6%) patients were admitted during the inflammation phase and jaundice phase, respectively. For patients admitted during the inflammation phase, mean (+/-SD) time from symptom-onset day to maximum ALT level was 7 (+/-3) days. For all patients, mean time from symptom-onset to maximum bilirubin level was 11 (+/-4) days. Mean LS during admission was 8.9 (+/-Pa (median, 8.4 kPa). LS was significantly correlated with serum bilirubin level, which was the only factor found to be significantly associated with the increased LS (>7.08 kPa). In all patients, LS increased gradually from the symptom-onset and peaked at 8-9 days later.

CONCLUSIONS:

Severe hepatic inflammation can affect the LS findings and thus, care is required when assessing fibrosis stage using LS measurement in patients with severe inflammation.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Bilirrubina / Doença Aguda / Estudos Retrospectivos / Alanina Transaminase / Técnicas de Imagem por Elasticidade / Hepatite A / Fígado Tipo de estudo: Estudo diagnóstico / Estudo observacional Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: The Korean Journal of Hepatology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Bilirrubina / Doença Aguda / Estudos Retrospectivos / Alanina Transaminase / Técnicas de Imagem por Elasticidade / Hepatite A / Fígado Tipo de estudo: Estudo diagnóstico / Estudo observacional Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: The Korean Journal of Hepatology Ano de publicação: 2008 Tipo de documento: Artigo