A Case of Primary Anti-D Alloimmunization by RHD (c.1227G>A) DEL Red Blood Cell Transfusion / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 169-173, 2016.
Artigo
em Coreano
| WPRIM
| ID: wpr-147857
ABSTRACT
The Rh blood group D antigen is the most immunogenic of all antigens, next to ABO antigens. Anti-D immunization is clinically important since it may cause clinical problems, such as severe hemolytic transfusion reactions and hemolytic disease of the newborn. DEL is an extremely weak D variant that cannot be detected by basic serologic typing and is typed as D-negative without the absorption-elution techniques and RHD genotyping. Of the DEL phenotype, RHD (c.1227G>A) allelic variant is the most common in Korea. The DEL phenotype has been considered to carry only a few D antigens to induce anti-D immunization, but a few cases have reported that this allelic variant is capable of inducing anti-D immunization in a D-negative recipient, for which it is clinical significant. Herein, we present a case of primary anti-D alloimmunization in a RhD negative patient after receiving RHD (c.1227G>A) DEL red cell transfusion identified by serological and molecular tests, including RHD genotyping.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Imunização
/
Transfusão de Eritrócitos
/
Eritrócitos
/
Reação Transfusional
/
Coreia (Geográfico)
Limite:
Humanos
/
Recém-Nascido
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Blood Transfusion
Ano de publicação:
2016
Tipo de documento:
Artigo
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