Evaluation of the estrogenic effects of dietary perinatal Trifolium pratense
Journal of Veterinary Science
;
: 121-126, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-148004
ABSTRACT
This study was designed to investigate the potential estrogenic effects of perinatal dietary phytoestrogens on the rat uterus. Pregnant rats were divided to three groups provided the following diets (1) rat chow, (2) rat chow with 7.5% Trifolium (T.) pratense, or (3) rat chow supplemented with 17beta-estradiol (0.5 mg/kg). The dams in each group were kept on the same diet during pregnancy and lactation. Female offspring were euthanized on day 21 at which time body and organ weights were recorded and tissue samples were taken for histology. Immunohistochemistry was performed to detect estrogen receptor alpha (ERalpha) and progesterone receptor (PR) levels. Our results revealed estrogen-like biological effects of perinatal T. pratense exposure. Relative uterus and ovary weights in the experimental groups were increased compared to control. The number of uterine glands and luminal epithelium heights were also increased. However, there were no statistically significant changes detected in the immunostaining intensity of ERalpha and PR between the groups.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho do Órgão
/
Útero
/
Peso Corporal
/
Lactação
/
Imuno-Histoquímica
/
Receptores de Progesterona
/
Ratos Wistar
/
Exposição Materna
/
Trifolium
/
Componentes Aéreos da Planta
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2011
Tipo de documento:
Artigo
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