QT Prolongation and Life Threatening Ventricular Tachycardia in a Patient Injected With Intravenous Meperidine (Demerol(R))
Korean Circulation Journal
;
: 342-345, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-148008
ABSTRACT
QT prolongation is a serious adverse drug effect, which is associated with an increased risk of Torsade de pointes and sudden death. Many drugs, including both cardiac and non-cardiac drugs, have been reported to cause prolongation of QT interval. Although meperidine has not been considered proarrhythmic, we present a unique case of a 16-year-old boy without an underlying cardiac disease, who developed polymorphic ventricular tachycardia, ventricular fibrillation and QT prolongation after an intravenous meperidine injection. He had no mutation in long QT syndrome genes (KCNQ1, KCNH2, and SCN5A), but single nucleotide polymorphisms were reported, including H558R in SCNA5A and K897T in KCNH2.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrilação Ventricular
/
Síndrome do QT Longo
/
Torsades de Pointes
/
Taquicardia Ventricular
/
Polimorfismo de Nucleotídeo Único
/
Morte Súbita
/
Cardiopatias
/
Meperidina
Limite:
Adolescente
/
Humanos
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2011
Tipo de documento:
Artigo
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