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Bilateral Triple-Negative Invasive Breast Cancer with a BRCA2 Mutation, and Glioblastoma: A Case Report and Literature Review / 한국유방암학회지
Journal of Breast Cancer ; : 108-111, 2017.
Artigo em Inglês | WPRIM | ID: wpr-148349
ABSTRACT
Breast cancer is the second leading cause of death among women in North America. Glioblastoma is the most common primary malignant central nervous system tumor in adults. The majority of hereditary breast cancers are associated with deleterious mutations in the BRCA1 and BRCA2 genes. Although few case reports have described the incidence of glioblastoma in patients previously diagnosed with breast cancer, any association between BRCA2 mutations and glioblastoma has not been demonstrated to date. Herein, we report a woman who is a carrier of a familial BRCA2 mutation, and was previously diagnosed with triple-negative breast cancer (TNBC) and subsequently with a second primary TNBC and glioblastoma. Further investigation is required to define the possible relationship between these two aggressive malignances and the BRCA2 mutation, which might be critical for the proper management and treatment of this disease.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Mama / Neoplasias da Mama / Sistema Nervoso Central / Incidência / Causas de Morte / Glioblastoma / Genes BRCA2 / Neoplasias de Mama Triplo Negativas / América do Norte Tipo de estudo: Estudo de incidência / Estudo prognóstico Limite: Adulto / Feminino / Humanos País/Região como assunto: América do Norte Idioma: Inglês Revista: Journal of Breast Cancer Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Mama / Neoplasias da Mama / Sistema Nervoso Central / Incidência / Causas de Morte / Glioblastoma / Genes BRCA2 / Neoplasias de Mama Triplo Negativas / América do Norte Tipo de estudo: Estudo de incidência / Estudo prognóstico Limite: Adulto / Feminino / Humanos País/Região como assunto: América do Norte Idioma: Inglês Revista: Journal of Breast Cancer Ano de publicação: 2017 Tipo de documento: Artigo