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rhBMP-2 using biphasic calcium phosphate block as a carrier induces new bone formation in a rat subcutaneous tissue / 대한치주과학회지
The Journal of the Korean Academy of Periodontology ; : 355-362, 2008.
Artigo em Inglês | WPRIM | ID: wpr-148368
ABSTRACT

PURPOSE:

The carrier for the delivery of bone morphogenetic proteins(BMPs) should also serve as a scaffold for new bone growth. In addition, predictable bone formation in terms of the volume and shape should be guaranteed. This study evaluated the ectopic bone formation of recombinant human BMP-2(rhBMP-2) using a micro macroporous biphasic calcium phosphate (MBCP mixture of betaTCP and HA) block as a carrier in a rat subcutaneous assay model. MATERIALS AND

METHODS:

Subcutaneous pockets were created on the back of 40 male Sprague-Dawley rats. In the pockets, rhBMP-2/MBCP and MBCP alone were implanted. The blocks were evaluated by histological and histometric parameters after a healing interval of 2 weeks (each 10 rats; MBCP and rhBMP-2/MBCP) or 8 weeks (each 10 rats; MBCP and rhBMP-2/MBCP).

RESULTS:

The shape and volume of the block was maintained stable over the healing period. No histological bone forming activity was observed in the MBCP alone sites after 2 weeks and there was minimal new bone formation at 8 weeks. In the rhBMP-2/MBCP sites, new bone formation was evident in the macropores of the block. The new bone area at 8 weeks was greater than at 2 weeks. There was a further increase in the quantity of new bone with the more advanced stage of remodeling.

CONCLUSIONS:

A MBCP block could serve as a carrier system for predictable bone tissue engineering using rhBMPs.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Osso e Ossos / Desenvolvimento Ósseo / Cálcio / Ratos Sprague-Dawley / Tela Subcutânea / Hidroxiapatitas Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: The Journal of the Korean Academy of Periodontology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Osso e Ossos / Desenvolvimento Ósseo / Cálcio / Ratos Sprague-Dawley / Tela Subcutânea / Hidroxiapatitas Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: The Journal of the Korean Academy of Periodontology Ano de publicação: 2008 Tipo de documento: Artigo