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Efficacy of Bicalutamide Monotherapy in Locally Advanced Prostate Cancer / 대한비뇨기과학회지
Korean Journal of Urology ; : 108-113, 2004.
Artigo em Coreano | WPRIM | ID: wpr-148830
ABSTRACT

PURPOSE:

Nonsteroidal antiandrogen monotherapy may be a treatment option for some patients with locally advanced prostate cancer. We report the efficacy, advantage, and adverse events of bicalutamide monotherapy in patients with locally advanced prostate cancer. MATERIALS AND

METHODS:

We retrospectively reviewed 13 patients with locally advanced prostate cancer who were treated with bicalutamide 150mg monotherapy. Serum PSA reduction was evaluated with periodic PSA follow-ups. If clinical progression was suspected, pelvic CT or bone scan was performed for the evaluation of disease progression. The changes of sexual function were assessed with the IIEF questionnaires prior to treatment and after 6 months of medication.

RESULTS:

Serum PSA declined to less than 2ng/ml within 3 months after treatment in most patients. A high serum PSA level was maintained in only 1 patient, and this patient showed disease progression. There were no significant differences between the mean scores of the pretreatment and post-treatment erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction (p>0.05). Of the 13 patients, 2 patients (15.5%) showed adverse events, such as breast pain and gynecomastia. However, the symptoms were mild to moderate. There was no withdrawal to medication due to drug-related adverse events.

CONCLUSIONS:

From the viewpoint of the fall in serum PSA levels after 3 months, bicalutamide monotherapy was effective in the treatment of locally advanced prostate cancer. There were benefits to the patients in terms of the quality of life parameters, sexual function, and tolerability, which make bicalutamide monotherapy an attractive treatment option for patients with locally advanced prostate cancer. (Korean J Urol 2004;45 108-113)
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Orgasmo / Próstata / Neoplasias da Próstata / Qualidade de Vida / Inquéritos e Questionários / Estudos Retrospectivos / Seguimentos / Progressão da Doença / Mastodinia / Ginecomastia Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Orgasmo / Próstata / Neoplasias da Próstata / Qualidade de Vida / Inquéritos e Questionários / Estudos Retrospectivos / Seguimentos / Progressão da Doença / Mastodinia / Ginecomastia Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2004 Tipo de documento: Artigo