Insights into the Transforming Growth Factor-beta Signaling Pathway in Cutaneous Melanoma
Annals of Dermatology
;
: 135-144, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-148979
ABSTRACT
Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-beta signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-beta is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-beta signaling in melanoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Robenidina
/
Nações Unidas
/
Distribuição Tecidual
/
Movimento Celular
/
Fator de Crescimento Transformador beta
/
Desenvolvimento Embrionário
/
Células Epiteliais
/
Homeostase
/
Melanoma
/
Metástase Neoplásica
Limite:
Gravidez
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2013
Tipo de documento:
Artigo
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