Aberrant Response of Selective Serotonin Reuptake Inhibitor in Two Patients with High N100 Amplitude Slope / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 341-347, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-149113
ABSTRACT
Serotonin is one of the most important neurotransmitters involved in the pathophysiology of depressive illness. The assessment of alteration of cerebral serotonin has been still controversial but interesting topic to study. Recently, increasing evidence has accumulated that the N100 amplitude slope reflects cerebral serotonin activity and treatment response of selective serotonin reuptake inhibitors (SSRIs). We report on two patients who showed abrupt mood changes and side effects after taking SSRI antidepressants. In both patients, aberrantly high N100 amplitude slopes were observed. Our cases suggest that the N100 amplitude slope may be a reliable indicator for predicting manic conversion and side effects in the SSRI treatment of depressive patients. Controlled studies are necessary to confirm whether a high N100 amplitude slope is a useful indicator of SSRI supersensitivity.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Serotonina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Neurotransmissores
/
Depressão
/
Antidepressivos
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2008
Tipo de documento:
Artigo
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