In vitro and in vivo antibacterial activity of Meliae fructus extract against Helicobacter pylori / 대한수의학회지
Korean Journal of Veterinary Research
;
: 105-113, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-149235
ABSTRACT
In this study, a medicinal herbal plant, Meliae fructus, was examined and screened for anti-Helicobacter (H.) pylori activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Meliae fructus extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Meliae fructus demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Meliae fructus extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Meliae fructus. It could be a promising native herbal treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas
/
Plantas Medicinais
/
Úlcera Gástrica
/
Urease
/
Programas de Rastreamento
/
Helicobacter pylori
/
Gerbillinae
/
Helicobacter
/
Melia
/
Etanol
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2012
Tipo de documento:
Artigo
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