Association of the CYP17 gene polymorphism with the risk of PCOS in Korean women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1306-1312, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-149363
ABSTRACT
OBJECTIVE:
To investigate whether polymorphism of CYP17 gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women.METHODS:
The 86 PCOS patients and 75 controls were enrolled. Blood samples were collected from 86 patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited on the control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype.RESULTS:
In women with A1A1 genotype, there was increased PCOS risk and this difference was statistically significant (OR 2.2 (CI 1-4.7)).CONCLUSION:
The results suggest that the CYP17 A1A1 genetic polymorphism might be associated with PCOS risk in Korean women.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome do Ovário Policístico
/
Polimorfismo Genético
/
Polimorfismo de Fragmento de Restrição
/
Conferências de Consenso como Assunto
/
Esteroide 17-alfa-Hidroxilase
/
Reação em Cadeia da Polimerase
/
Genótipo
/
Menstruação
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS