Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?
Diabetes & Metabolism Journal
;
: 468-477, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-149427
ABSTRACT
Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic beta-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been identified to date. A correct genetic diagnosis is important as it often leads to personalized treatment for those with diabetes and enables predictive genetic testing for their asymptomatic relatives. Next-generation sequencing may provide an efficient method for screening mutations in this form of diabetes as well as identifying new MODY genes. In this review, I discuss a current update on MODY in the literatures and cover the studies that have been performed in Korea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testamentos
/
Testes Genéticos
/
Programas de Rastreamento
/
Diabetes Mellitus Tipo 2
/
Diagnóstico
/
Coreia (Geográfico)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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