Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease
Endocrinology and Metabolism
;
: 105-109, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-150111
ABSTRACT
Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ásia
/
Recidiva
/
Testes Sorológicos
/
Redução de Peso
/
Doença Celíaca
/
Doença de Graves
/
Prevalência
/
Genes MHC da Classe II
/
Predisposição Genética para Doença
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo de prevalência
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
/
Europa
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo
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