Expression of Survivin in Non-Small Cell Lung Carcinoma: Relationship to Tumor Biology and Prognosis in Surgically Treated Patients
Korean Journal of Pathology
; : 151-157, 2005.
Article
em Ko
| WPRIM
| ID: wpr-150295
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Survivin, a novel member of inhibitor-of-apoptosis, is undetectable in most terminally differentiated nonproliferative adult tissue, but is overexpressed in some human malignancies. The survivin gene expression is repressed by binding of wild-type p53 with the survivin promotor. In this study, we investigated the prevalence of survivin expression, its association with p53 overexpression and proliferative index, and clinicopathological significance in non-small cell lung carcinomas (NSCLC). METHODS: Immunohistochemical stainings were performed in 59 cases of primary NSCLC for survivin, p53 and Ki-67. Correlations between the survivin expression, p53 overexpression and Ki-67 labeling index were analyzed. RESULTS: Survivin expression was detected in 47 carcinomas (80%) with nuclear immunoreactivity (56%). Survivin nuclear immunoreactivity revealed significantly worse prognosis in NSCLC patients (p=0.003), and correlated with lymph node metastasis (p=0.014), lymphovascular invasion (p=0.032), p53 overexpression, and Ki-67 labeling index (KI 24.2 +/- 6.9, p=0.045). Survivin expression was not correlated with histological type and pT status. CONCLUSIONS: High incidence of survivin overexpression in NSCLC suggests that survivin is involved in lung carcinogenesis, and nuclear expression of survivin can be used as a poor prognostic predictor in NSCLC patients. Expression of mutant p53 seems to be a possible mechanism of survivin up-regulation in NSCLC.
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Assunto principal:
Prognóstico
/
Biologia
/
Expressão Gênica
/
Regulação para Cima
/
Incidência
/
Prevalência
/
Proliferação de Células
/
Carcinogênese
/
Pulmão
/
Linfonodos
Tipo de estudo:
Incidence_studies
/
Prevalence_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Pathology
Ano de publicação:
2005
Tipo de documento:
Article