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The Effects of Galantamine Treatment on Attention and Its Relationship with Cognition and Activities of Daily Living in Patients with Mild to Moderate Alzheimer's Disease
Journal of Clinical Neurology ; : 66-72, 2015.
Artigo em Inglês | WPRIM | ID: wpr-150528
ABSTRACT
BACKGROUND AND

PURPOSE:

The positive effects of galantamine on cognition and activities of daily living (ADL) in Alzheimer's disease (AD) are thought to be mediated via improvements in attention. The purpose of this study was to determine the effect of galantamine on attention in AD patients using a computerized attention test and to elucidate the relationship between improvements in attention and change in cognition and ADL.

METHODS:

In this multicenter, open-label, prospective study, patients with mild to moderate AD received galantamine and then submitted to computerized attention tests, the Alzheimer's Disease Assessment Scale-cognitive subscale, and instrumental ADL (IADL) at baseline, 4 weeks, and 12 weeks. The differences in reaction time on computerized tests were explored relative to the changes in cognition and IADL.

RESULTS:

After 12 weeks of taking the trial medication there was a significant reduction from baseline levels in the choice reaction time (baseline, 5,216+/-3,650 sec; 12 weeks, 4,139+/-2,920 sec; p<0.01) and the simple reaction time (baseline, 1,089+/-782 sec; 12 weeks, 908+/-606 sec; p<0.01). Correlation analyses of changes in choice or simple reaction times relative to cognition and ADL measures yielded no significant associations. The improvement in attention observed at 4 weeks of galantamine treatment was not associated with any significant changes in outcome measures at the end of trial.

CONCLUSIONS:

This study found no significant association between the improvement in attention after treatment with galantamine and changes in cognition and ADL in patients with mild to moderate AD, despite the significant improvement in attention over the course of the treatment.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tempo de Reação / Atividades Cotidianas / Estudos Prospectivos / Avaliação de Resultados em Cuidados de Saúde / Cognição / Doença de Alzheimer / Galantamina Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional Limite: Humanos Idioma: Inglês Revista: Journal of Clinical Neurology Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tempo de Reação / Atividades Cotidianas / Estudos Prospectivos / Avaliação de Resultados em Cuidados de Saúde / Cognição / Doença de Alzheimer / Galantamina Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional Limite: Humanos Idioma: Inglês Revista: Journal of Clinical Neurology Ano de publicação: 2015 Tipo de documento: Artigo