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Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model
Journal of Korean Medical Science ; : 533-541, 2000.
Artigo em Inglês | WPRIM | ID: wpr-150738
ABSTRACT
The purpose of this study was to determine whether esterification of dehydroepiandrosterone with aspartate (DHEA-aspartate) could reduce peroxisomal proliferation induced by DHEA itself, without loss of antiosteoporotic activity. Female Sprague-Dawley rats were ovariectomized, then DHEA or DHEA-aspartate was administered intraperitoneally at 0.34 mmol/kg BW 3 times a week for 8 weeks. DHEA-aspartate treatment in ovariectomized rats significantly increased trabeculae area in tibia as much as DHEA treatment. Urinary Ca excretion was not significantly increased by DHEA or DHEA-aspartate treatment in ovariectomized rats, while it was significantly increased by ovariectomy. Osteocalcin concentration and alkaline phosphatase activity in serum and cross linked N-telopeptide type I collagen level in urine were not significantly different between DHEA-aspartate and DHEA treated groups. DHEA-aspartate treatment significantly reduced liver weight and hepatic palmitoyl-coA oxidase activity compared to DHEA treatment. DHEA-aspartate treatment maintained a nearly normal morphology of peroxisomes, while DHEA treatment increased the number and size of peroxisomes in the liver. According to these results, it is concluded that DHEA-aspartate ester has an inhibitory effect on bone loss in ovariectomized rats with a marked reduction of hepatomegaly and peroxisomal proliferation compared to DHEA.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho do Órgão / Osteoporose / Tíbia / Triglicerídeos / Ovariectomia / Biomarcadores / Adjuvantes Imunológicos / Cálcio / Ratos Sprague-Dawley / Ácido Aspártico Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho do Órgão / Osteoporose / Tíbia / Triglicerídeos / Ovariectomia / Biomarcadores / Adjuvantes Imunológicos / Cálcio / Ratos Sprague-Dawley / Ácido Aspártico Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2000 Tipo de documento: Artigo