Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study / 부인종양
Journal of Gynecologic Oncology
;
: 188-195, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-150980
ABSTRACT
OBJECTIVE:
To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors.METHODS:
Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed.RESULTS:
One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies.CONCLUSION:
Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ovário
/
Recidiva
/
Prontuários Médicos
/
Análise Multivariada
/
Estudos Retrospectivos
/
Seguimentos
/
Quimioterapia Adjuvante
/
Pré-Menopausa
/
Intervalo Livre de Doença
/
Fertilidade
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS