Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice
The Korean Journal of Pain
; : 206-209, 2009.
Article
em Ko
| WPRIM
| ID: wpr-151017
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB. METHODS: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 mg/kg, 100 mg/kg, 150 mg/kg) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 mg/kg, 100 mg/kg) was administered and the withdrawal latency was measured using the Hargreaves method. RESULTS: In the formalin test, EOOB (50 mg/kg, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined. CONCLUSIONS: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Medição da Dor
/
Ocimum basilicum
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Ocimum
/
Formaldeído
/
Mãos
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Medicina Tradicional
Limite:
Animals
Idioma:
Ko
Revista:
The Korean Journal of Pain
Ano de publicação:
2009
Tipo de documento:
Article