Activation of Caspase-3 During Photoreceptor Degeneration in rd Mouse Retina
Journal of the Korean Ophthalmological Society
;
: 365-372, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-151066
ABSTRACT
Retinal degeneration caused by a hereditary defect in the genome is reported in a few animals and it leads to blindness. rd mouse is one of the well studied animal models for retinal degeneration. The retinal degeneration of rd mouse is caused by a mutation on cGMP-phosphodiesterase(PDE). Caspase activation has been implicated for apoptosis. In this study, we examined the activation of caspase-3 during photoreceptor degeneration in rdmouse. Photoreceptor degeneration of rd mouse occured at PD 9 and disappeared at PD 21.In addition, we observed the active form of caspase-3 in the retinal degeneration of rd mouse. In conclusion, the cell death pattern of photoreceptor degeneration in rd mouse seemed to be an apoptosis rather than necrosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Retina
/
Degeneração Retiniana
/
Cegueira
/
Genoma
/
Morte Celular
/
Apoptose
/
Modelos Animais
/
Caspase 3
/
Necrose
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2001
Tipo de documento:
Artigo
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