Association of the COMT Gene Polymorphism with the Risk of PCOS in Korean Women / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 97-104, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-151310
ABSTRACT
OBJECTIVE:
To investigate whether polymorphism of Catechol-O-methyltransferase (COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women.METHODS:
One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype.RESULTS:
In women with COMT(LL) genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51).CONCLUSION:
The results suggest that the COMT(LL) genetic polymorphism might be associated with PCOS risk in Korean women.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome do Ovário Policístico
/
Polimorfismo Genético
/
Polimorfismo de Fragmento de Restrição
/
Conferências de Consenso como Assunto
/
Catecol O-Metiltransferase
/
Reação em Cadeia da Polimerase
/
Genótipo
/
Menstruação
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Fertility and Sterility
Ano de publicação:
2006
Tipo de documento:
Artigo
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