The Galectin 3 Expression in Benign and Malignant Breast Tumor
Journal of the Korean Surgical Society
;
: 459-464, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-151773
ABSTRACT
PURPOSE:
Galectin 3 is a beta-galactoside binding protein that is involved in various biological processes such as cell adhesion, migration, cell growth, tumor progression and metastasis. Although the precise acting mechanisms of Galectin 3 are unclear, it have been reported that the expression of Galectin 3 may related to tumor progression and metastasis. We investigated the immunohistochemical expression of Galectin 3 in 57 cases of benign and malignant breast neoplasm to evaluate the relation of a Galectin 3 expression to malignancy of breast neoplasm and the acting mechanism of Galectin 3.METHODS:
Twenty fibroadenomas, 7 intraductal papillomas, 10 intraductal carcinomas and 20 invasive ductal carcinomas were studied. Immunostaining of Galectin 3 was evaluated in comparison with that of the internal controls, and the intensity of immunostaining was semiquantitatively graded on an intensity scale of 0 to 3.RESULTS:
The normal ductal epithelium of the breast showed strong immunoreactivity with an intensity 2 to 3. The staining gradually and significantly decreased in accordance with the histopathological type and tumor progression from a fibroadenoma, intraductal papilloma, ductal carcinoma in situ and invasive ductal carcinoma (P<0.001). In particular, the expression of galection-3 was prominently decreased in invasive ductal carcinoma.CONCLUSION:
The galectin-3 expression pattern suggests that progression from benign breast tumor to malignant breast tumor leads to a reduced expression of galectin-3.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Papiloma
/
Fenômenos Biológicos
/
Mama
/
Neoplasias da Mama
/
Proteínas de Transporte
/
Adesão Celular
/
Movimento Celular
/
Papiloma Intraductal
/
Fibroadenoma
/
Carcinoma Intraductal não Infiltrante
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
2007
Tipo de documento:
Artigo
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