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Changes in dead space/tidal volume ratio and pulmonary mechanics after surfactant replacement therapy in respiratory distress syndrome of the newborn infants
Journal of Korean Medical Science ; : 51-56, 2001.
Artigo em Inglês | WPRIM | ID: wpr-151878
ABSTRACT
This study was performed to elucidate the mechanism of improved oxygenation after surfactant replacement therapy in respiratory distress syndrome (RDS) of the newborn infants. In 26 newborns with RDS, end tidal-CO2 tension (PetCO2), arterial blood gas analysis and pulmonary function tests were measured at baseline, 30 min, 2 hr and 6 hr after surfactant administration. The changes in dead space/tidal volume ratio (VD/VT ratio=(PaCO2-PetCO2)/PaCO2), oxygenation index and arterial-alveolar partial pressure difference for oxygen ((A-a)DO2) were elucidated and correlated with pulmonary mechanics. Oxygenation index and (A-a)DO2 improved, and VD/VT ratio decreased progressively after surfactant administration, becoming significantly different from the baseline at 30 min and thereafter with administration of surfactant. Pulmonary mechanics did not change significantly during the observation period. VD/VT ratio showed close correlation with OI and (A-a)DO2, but not with pulmonary mechanics. These results suggest that decreased physiologic dead space resulting from the recruitment of atelectatic alveoli rather than improvement in pulmonary mechanics is primarily responsible for the improved oxygenation after surfactant therapy in the RDS of newborn.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome do Desconforto Respiratório do Recém-Nascido / Surfactantes Pulmonares / Troca Gasosa Pulmonar / Espaço Morto Respiratório / Volume de Ventilação Pulmonar / Resistência das Vias Respiratórias / Complacência Pulmonar / Pulmão Limite: Humanos / Recém-Nascido Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome do Desconforto Respiratório do Recém-Nascido / Surfactantes Pulmonares / Troca Gasosa Pulmonar / Espaço Morto Respiratório / Volume de Ventilação Pulmonar / Resistência das Vias Respiratórias / Complacência Pulmonar / Pulmão Limite: Humanos / Recém-Nascido Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2001 Tipo de documento: Artigo