Association among Histopathology, Clinical Manifestation, and Ultrasonographic Grades in Pediatric Non-alcoholic Fatty Liver Disease / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 158-165, 2011.
Article
em Ko
| WPRIM
| ID: wpr-151918
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is the progressive form of non-alcoholic fatty liver disease (NAFLD), and its prevalence is increasing worldwide. Liver biopsy remains the best way to diagnose NASH and establish the presence of fibrosis, but has not been performed easily in children because of its invasiveness. We analyzed the ultrasonographic and histopathologic findings of pediatric NAFLD patients, and studied to find their association with clinical characteristics and laboratory findings. METHODS: The study involved 18 obese children ranging from 7 to 15 years of age, who were diagnosed with NASH by liver biopsy. We performed the abdomen ultrasonography before the liver biopsy. We reviewed their pathology slides and classified them by NASH CRN (Clinical Research Network) scoring system. We also reviewed the abdomen ultrasonographic findings of the patients and classified them into grade of 1, 2, and 3. We reviewed the medical records of the patients and investigated their clinical characteristics and laboratory findings. RESULTS: The ultrasonographic grades had significant association with NAFLD activity score, grade of steatosis amount, ballooning change, and portal inflammation. Serum triglyceride level was significantly higher in patients who showed high grade steatosis and high NAFLD activity score. CONCLUSIONS: This study showed that serum triglycerides and ultrasonographic findings are highly correlated with pathologic findings in children with NAFLD.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Triglicerídeos
/
Índice de Gravidade de Doença
/
Estudos Retrospectivos
/
Progressão da Doença
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Biópsia por Agulha Fina
/
Fígado Gorduroso
/
Obesidade
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Child
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Female
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Humans
/
Male
Idioma:
Ko
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2011
Tipo de documento:
Article