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Prevalence of Occupational Asthma and Exposure Level of Pharmaceutical Dust of Workers in a Pharmaceutical Company / 대한산업의학회지
Korean Journal of Occupational and Environmental Medicine ; : 94-102, 2006.
Artigo em Coreano | WPRIM | ID: wpr-152027
ABSTRACT

OBJECTIVES:

After the investigation of one worker with occupational asthma, we surveyed the prevalence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company.

METHODS:

Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to pharmaceutical dust in an academic allergic disease center.

RESULTS:

Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high.

CONCLUSIONS:

This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input of raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sistema Respiratório / Asma / Pele / Espirometria / Testes de Provocação Brônquica / Alérgenos / Programas de Rastreamento / Prevalência / Inquéritos e Questionários / Cloreto de Metacolina Tipo de estudo: Estudo de prevalência / Estudo prognóstico / Estudo de rastreamento Idioma: Coreano Revista: Korean Journal of Occupational and Environmental Medicine Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sistema Respiratório / Asma / Pele / Espirometria / Testes de Provocação Brônquica / Alérgenos / Programas de Rastreamento / Prevalência / Inquéritos e Questionários / Cloreto de Metacolina Tipo de estudo: Estudo de prevalência / Estudo prognóstico / Estudo de rastreamento Idioma: Coreano Revista: Korean Journal of Occupational and Environmental Medicine Ano de publicação: 2006 Tipo de documento: Artigo