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Association between RASSF1A Methylation and Clinicopathological Factors in Patients with Squamous Cell Carcinoma of Lung / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 265-272, 2004.
Artigo em Coreano | WPRIM | ID: wpr-152128
ABSTRACT

BACKGROUND:

RASSF1A, which is one of tumor suppressor genes, is frequently inactivated by hypermethylation of the promoter region in a variety of human cancers, including lung cancer. This study was performed to investigate the association between RASSF1A methylation and the clinicopathological factors in patients with squamous cell carcinoma of the lung.

METHODS:

Eighty-one samples from the patients with squamous cell carcinoma of lung were examined. The promoter methyation of RASSF1A was analyzed by methylation specific PCR and sequencing. Statistical analysis was made to examine the association between RASSF1A methylation and the clinicopathological parameters.

RESULTS:

RASSF1A methylation was observed in 37.0 % (30 of 81) of the patients with squamous cell carcinoma of the lung. RASSF1A methylation was found to be associated with cellular differentiation(p=0.0097) and the overall survival(p=0.0635). However, there was no association between RASSF1A methylation and the other clini?copathological parameters, such as the pathological TNM stage, the recurrence rate, lymph node invasion and the amount of cigarettes smoked.

CONCLUSION:

RASSF1A methylation might be associated with a poor prognosis in patients with squamous carcinoma of the lung. A larger scale study is needed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Recidiva / Fumaça / Carcinoma de Células Escamosas / Reação em Cadeia da Polimerase / Genes Supressores de Tumor / Regiões Promotoras Genéticas / Produtos do Tabaco / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Recidiva / Fumaça / Carcinoma de Células Escamosas / Reação em Cadeia da Polimerase / Genes Supressores de Tumor / Regiões Promotoras Genéticas / Produtos do Tabaco / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2004 Tipo de documento: Artigo