A Case of Hereditary Spherocytosis Coexisting with Gilbert's Syndrome / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 166-169, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-152218
ABSTRACT
We recently encountered a case of hereditary spherocytosis coexisting with Gilbert's syndrome. Patient was initially diagnosed with Gilbert's syndrome and observed, but other findings suggestive of concurrent hemolysis, such as splenomegaly and gallstones were noted during the follow-up period. Therefore, further evaluations, including a peripheral blood smear, osmotic fragility test, autohemolysis test, and red blood cell membrane protein test were performed, and coexisting hereditary spherocytosis was diagnosed. Genotyping of the conjugation enzyme uridine diphosphate-glucuronosyltransferase was used to confirm Gilbert's syndrome. Because of the high prevalence rates and similar symptoms of these 2 diseases, hereditary spherocytosis can be masked in patients with Gilbert's syndrome. In review of a case and other article, the possibility of the coexistence of these 2 diseases should be considered, especially in patients with unconjugated hyperbilirubinemia who also have splenomegaly and gallstones.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esferocitose Hereditária
/
Esplenomegalia
/
Cálculos Biliares
/
Glucuronosiltransferase
/
Polimorfismo de Nucleotídeo Único
/
Eritrócitos
/
Genótipo
/
Doença de Gilbert
/
Hemólise
/
Hiperbilirrubinemia
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2013
Tipo de documento:
Artigo
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