Influence of History of Alcohol Ingestion on AST and ALT Following Enflurane Anesthesia in Gastrectomy Patients / 대한마취과학회지

ABSTRACT

BACKGROUND: There are many factors including the operation site, duration of anesthesia, preoperative liver function and hepatitis, which cause postoperative hepatic dysfunction. The purpose of this study is to evaluate postoperative liver function with respect to a history of alcohol intake. METHODS: Seventy-five patients were divided into 2 groups44 patients without alcohol intake (non-alcohol group), 31 patients with alcohol intake (alcohol group). All patients were anesthetized with about 1.5 vol% of enflurane combined with 50% nitrous oxide and 50% oxygen. AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were measured before anesthesia, 1, 3 and 7 days after surgery in both groups, respectively. Postoperative AST and ALT values were compared to preoperative values within each group, and were also compared between groups. RESULTS: In the alcohol group, postoperative AST and ALT values were significantly higher than preoperative values (P < 0.05). In addition, postoperative ALT values significantly increased in the 1st and 7th day over the upper normal limit of ALT (P < 0.05). In the non-alcohol group, postoperative AST and ALT values increased over preoperative values, but those levels were within the normal limits of AST and ALT. CONCLUSIONS: The data suggest that when surgery can reduce hepatic blood flow, patients with a history of alcohol ingestion may have a risk of raised liver-derived enzyme in the first seven postoperative days.